OpenCRAVAT

It exposes MCP tools that let an MCP client:

- Discover which OpenCRAVAT annotators are being run (a curated default set).
- Inspect annotator output schemas (field names/types/descriptions).
- Annotate variants by:

- genomic coordinates (chrom/pos/ref/alt). Accepts only GRCh38/hg38 coordinates.
- dbSNP rsID
- ClinGen Allele Registry ID (CAid)
- HGVS (g./c./p.)

To connect to Claude, followthese instructions. Use the URL above, and do not set up auth. No user-specific data is needed for the MCP to work. Remember to enable the MCP for your chat.

To connect to your MCP server from Claude Desktop, followAnthropic's Quickstartand within Claude Desktop go to Settings > Developer > Edit Config.

{ "mcpServers": { "OpenCRAVAT": { "command": "npx", "args": [ "mcp-remote", "http://localhost:8787/mcp" ] } } }

Restart Claude and you should see the tools become available.

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